Schedule
2023 lecture recordings: Panopto.
06/02/23: Introduction I (Erik Abner, Kaur Alasoo)
- Aims, outline, example applications.
- Biological concepts: Central dogma of molecular biology, DNA sequencing.
- Computational concepts:
13/02/23: Introduction to workflow managers and automation
20/02/23: Introduction II (Erik Abner)
27/02/23: Gene expression (Kaur Alasoo)
- Guilt-by-association approach to understanding gene function
- Biological concepts: RNA transcription, RNA-seq, Gene ontology
- Computational concepts: PCA, multiple testing, FDR, permutation, computational workflows.
06/03/23: Sequence alignment (Priit Adler)
- Biological concepts: Reference genomes, genetic variation.
- Computational concepts: Exact matching, hashing, edit distance, dynamic programming.
13/03/23: Genetic variation (Kaur Alasoo) + Introduction to projects
- Biological concepts: SNPs, indels, LD, genotyping, CNV, Recombination
- Computational concepts: variant calling, missing data imputation
23/03/23: Protein expression and variance decomposition (Kaur Alasoo)
- Biological concepts: protein expression, flow cytometry
- Computational concepts: linear mixed models, variance decomposition.
27/03/23: Detecting genetic associations (Kaur Alasoo)
03/04/23: Statistical colocalisation and fine mapping (Kaur Alasoo)
- Using genetics to understand gene function
- Biological concepts: linkage disequilibrium (LD), pleiotropy
- Computational concepts: Bayesian statistics, model comparison.
10/04/23: Transcriptional regulation and functional fine mapping (Kaur Alasoo)
- Biological concepts: Transcription factors, Chip-seq, sequence specificities, chromatin accessibility
- Computational concepts: Peak calling, signal thresholding
17/04/23: Transcript expression and splicing (Kaur Alasoo)
- Biological concepts: Alternative promoters, splicing, polyadenylation
- Computational concepts: Expectation-Maximisation (EM) algorithm.
12/06/23: Project presentations (link)
- There may be some minor changes in the schedule (due to guest lecturers or some other force majeure)