The lecture recordings are available from Panopto.
You can download the slides from OwnCloud
08/02/21: Introduction I (Erik Abner, Kaur Alasoo)
- Aims, outline, example applications.
- Biological concepts: Central dogma of molecular biology, DNA sequencing.
- Computational concepts:
15/02/21: Introduction II (Erik Abner)
22/02/21: Sequence alignment (Priit Adler)
- Biological concepts: Reference genomes, genetic variation.
- Computational concepts: Exact matching, hashing, edit distance, dynamic programming.
01/03/21: Gene expression (Kaur Alasoo)
- Guilt-by-association approach to understanding gene function
- Biological concepts: RNA transcription, RNA-seq, Gene ontology
- Computational concepts: PCA, multiple testing, FDR, permutation, computational workflows.
08/03/21: Genetic variation (Kaur Alasoo)
- Biological concepts: SNPs, indels, LD, genotyping, CNV, Recombination
- Computational concepts: variant calling, missing data imputation
11/03/21: Developing scientific workflows with Nextflow (Nurlan Kerimov) + consultation session.
15/03/21: Protein expression and variance decomposition (Kaur Alasoo)
- Biological concepts: protein expression, flow cytometry
- Computational concepts: linear mixed models, variance decomposition.
22/03/21: Detecting genetic associations (Leopold Parts/Kaur Alasoo)
29/03/21: Statistical colocalisation and fine mapping (Kaur Alasoo)
- Using genetics to understand gene function
- Biological concepts: linkage disequilibrium (LD), pleiotropy
- Computational concepts: Bayesian statistics, model comparison.
05/04/21: Transcriptional regulation and functional fine mapping (Kaur Alasoo)
- Biological concepts: Transcription factors, Chip-seq, sequence specificities, chromatin accessibility
- Computational concepts: Peak calling, signal thresholding
12/04/21: Transcript expression and splicing (Kaur Alasoo)
- Biological concepts: Alternative promoters, splicing, polyadenylation
- Computational concepts: Expectation-Maximisation (EM) algorithm.
31/05/21: Project presentations - CANCELLED
- There may be some minor changes in the schedule (due to guest lecturers or some other force majeure)